Modeling of submicrometer gate GaAs field effect transistors

Before describing the mainFet modelings today available, the main technological evolutions ofMesfet andTegfet are summarized. It is brought some information on the various physical effects that occur in the devices and that must be taken into account in the models. It is shown that the different kinds of modelings (Monte Carlo, two dimensional, one dimensional) constitute a continuous chain, where the different elements appear strictly complementary. Finally, the present situation concerning modeling ofMesfet andTegfet will be presented.     

一种制做三维牙——颌骨光弹性模型的新方法

本文提出一种用“整体浇注法”制做三维牙——颌骨光弹性模型的新方法,即用价格便宜的石膏做阴模,先制出与真实牙几何相似的牙光弹性模型和模拟牙周膜的乳胶套,将它们粘接好,然后将其放入颌骨石膏阴模的适当位置,浇入环氧树脂混合液,用“二次固化法”进行固化,即可制成三维牙——颌骨整体光弹性模型。此法能保证模型与实物的严格几何相似和牙周的边界条件相似,使实验精度大大提高且工艺简单、成本低。     

基于IPv6技术的网络家电控制电路设计

随着信息技术的发展,计算机网络越来越深入平时的生产生活中,家用电器网络化已经成为一种发展趋势。本文实现一种基于IPv6技术的家电网络控制电路的硬件设计。应用该方法设计的家电系统在智能化及网络化具有较好性能。     

企业无线网络架设与安全

通过对当前企业无线网络的需求分析,阐述了无线技术和无线网络的发展历史和过程,结合无线网络在家庭用户和企业间架设的不同特点,提出了针对企业用户的无线网络架设的解决方案,同时也阐明了安全问题的重要性。最后结合某公司无线网络架设实例,论述解决方案的设计、实现过程。     

iPSC-Cardiomyocyte Models of Brugada Syndrome—Achievements,Challenges and Future Perspectives

Brugada syndrome (BrS) is an inherited cardiac arrhythmia that predisposes to ventricular fibrillation and sudden cardiac death. It originates from oligogenic alterations that affect cardiac ion channels or their accessory proteins. The main hurdle for the study of the functional effects of those variants is the need for a specific model that mimics the complex environment of human cardiomyocytes. Traditionally, animal models or transient heterologous expression systems are applied for electrophysiological investigations, each of these models having their limitations. The ability to create induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), providing a source of human patient-specific cells, offers new opportunities in the field of cardiac disease modelling. Contemporary iPSC-CMs constitute the best possible in vitro model to study complex cardiac arrhythmia syndromes such as BrS. To date, thirteen reports on iPSC-CM models for BrS have been published and with this review we provide an overview of the current findings, with a focus on the electrophysiological parameters. We also discuss the methods that are used for cell derivation and data acquisition. In the end, we critically evaluate the knowledge gained by the use of these iPSC-CM models and discuss challenges and future perspectives for iPSC-CMs in the study of BrS and other arrhythmias.     

先进微处理器体系结构及其发展趋势*

为了进一步提高微处理器性能,提出了多种新颖的体系结构,如多核、流处理、PIM、可重构、多态等.这些新的体系结构从不同角度对微处理器发展中的问题提出了解决方法.概述了这些体系结构的特点,并对未来体系结构的发展趋势进行了预测.     

求解QoS组播路由问题的满意优化方法*

通过分析目前QoS路由优化的一些关键问题,提出一种基于满意优化原理的QoS路由多目标满意优化求解模型,使之更适合解决QoS路由优化问题.仿真结果表明,该算法能极大地缩短路由求解时间,具有很强的适用性和灵活性.     

The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury

Acute lung injury (ALI) afflicts approximately 200,000 patients annually and has a 40% mortality rate. The COVID-19 pandemic has massively increased the rate of ALI incidence. The pathogenesis of ALI involves tissue damage from invading microbes and, in severe cases, the overexpression of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). This study aimed to develop a therapy to normalize the excess production of inflammatory cytokines and promote tissue repair in the lipopolysaccharide (LPS)-induced ALI. Based on our previous studies, we tested the insulin-like growth factor I (IGF-I) and BTP-2 therapies. IGF-I was selected, because we and others have shown that elevated inflammatory cytokines suppress the expression of growth hormone receptors in the liver, leading to a decrease in the circulating IGF-I. IGF-I is a growth factor that increases vascular protection, enhances tissue repair, and decreases pro-inflammatory cytokines. It is also required to produce anti-inflammatory 1,25-dihydroxyvitamin D. BTP-2, an inhibitor of cytosolic calcium, was used to suppress the LPS-induced increase in cytosolic calcium, which otherwise leads to an increase in proinflammatory cytokines. We showed that LPS increased the expression of the primary inflammatory mediators such as toll like receptor-4 (TLR-4), IL-1β, interleukin-17 (IL-17), TNF-α, and interferon-γ (IFN-γ), which were normalized by the IGF-I + BTP-2 dual therapy in the lungs, along with improved vascular gene expression markers. The histologic lung injury score was markedly elevated by LPS and reduced to normal by the combination therapy. In conclusion, the LPS-induced increases in inflammatory cytokines, vascular injuries, and lung injuries were all improved by IGF-I + BTP-2 combination therapy.     

Adsorption Mechanism and Electrochemical Properties of Methyl Blue onto Magnetic CoxCu(1–x)Fe2O4 Nanoparticles Prepared via an Alcohol Solution of Nitrate Combustion and Calcination Process

Journal of Inorganic and Organometallic Polymers and Materials - Magnetic CoxCu(1–x)Fe2O4 nanoparticles were prepared via an alcohol solution of nitrate combustion and calcination process....     

原位反应自发渗透法TiC／AZ91D镁基复合材料及AZ91D镁合金的拉伸变形与断裂行为

利用原位反应自发渗透技术合成了47．5％碳化钛TiC（体积分数，下同）增强AZ91D镁基复合材料，对比研究了该复合材料与铸态镁合金AZ91D基体的室温与高温拉伸变形行为，观察了拉伸断口微观组织形貌，并分析了这两种材料的断裂特征。结果表明，TiC／Mg复合材料具有良好的高温力学性能，在拉伸变形速率为0．001s^-1以及温度为723K，时其拉伸强度可达91．1MPa，而此时相同变形条件下的铸态AZ91D镁合金拉伸断裂强度只有41．1MPa，增幅达120％。而在室温下，镁基复合材料的拉伸断裂强度仅高出基体铸态镁合金23．4％。镁基复合材料的断裂应变较低，高低温时均表现为脆性断裂；而镁合金则由室温下的脆性断裂向高温下的韧性断裂过渡。